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  • "Joeys" started this thread

Posts: 61

Reg: Apr 29th 2010

Location: Sussex

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Wednesday, September 4th 2013, 4:50pm

E2 Not rising

Hi Girls I need your help. Been looking at google for hours and cant see anything relevant to me.

I started an IVF cycle 5 days ago. I was on the max dose of drugs as I have had high FSH previously (although this cycle it was 6 - which I believe is normal?). I had two days of stimulation and then my clinic told me to stop stims and start taking clomid and viagra as my E2 level had not changed.

Today I expected to be put back on the stims but the clinic called and said my E2 had fallen! And currently its 58.

Can anyone shed any light on what the Hell is going on?

I'm not taking any injectable stims and cant understand why my clinic wont put me on them? When I asked they said the Clomid was my stimulation drug.

Please can any of you help?
so stressed

Posts: 1,193

Reg: May 30th 2010

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Wednesday, September 4th 2013, 10:12pm

Big hugs hope you get some answers soon sorry I'm no help but didn't want to read and run.

In the worst case scenario they might cancel your cycle but will hopefully come up with a plan for next time.

xx Rianon

Posts: 262

Reg: Apr 27th 2012

Location: Lancashire

Children: One beautiful boy. Centre of our world.

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Thursday, September 5th 2013, 1:52pm


I can't help but I'm really sorry you're having this stress.

Ring your clinic and ask them to explain what is going on - that is only reasonable on their part.

Good luck with it all

Jenny x

Posts: 34

Reg: Aug 18th 2013

Location: London

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Friday, September 20th 2013, 1:16pm

A slow down in an E2 rise usually means the follicles are maxed out or are being under-stimulated.
Its really difficult to predict exact level of E2 as each body, each cycle is different. but, in general, a 'good' estradiol level is between 150- 500 pg/ml on day eight of an IVF cycle. Approximate doubling of the day eight value every 48 hours is a positive sign of continued follicle development.
According to a 2004 study published in the Journal of Assisted Reproduction and Genetics, levels lower than75 pg/ml were predictive of cycle cancellation.
All is not lost if an in-vitro cycle is canceled. Be gentle with yourself if a cycle is cancelled and don't stop believing in a positive outcome.

:) :thumbsup:




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Friday, September 20th 2013, 6:37pm

Hi Joeys,
I am sorry. I know how stressful this is :hugs:

Low FSH levels are masked by high E2 levels at the beginning of the cycle (on day 1 they both have to be low). FSH stimulates the production of E2. If E2 is high at the start then your body doesn't need to make any FSH, so that is low that cycle.
If E2 is high at the start of the cycle then it is less likely that you will respond to stimming drugs. If E2 does then not rise or if it falls it means that there are probably no mature follicles growing in that particular cycle, giving you more stimulating drugs (which are basically FSH) will not change this.

Clomid is a different type of drug and it is also used to stimulate your ovaries and can be used instead or together with inject able drugs. It works by blocking estrogen (E2 is a type of estrogen) receptors, making the body 'think' there is no estrogen. When this happens, the body produces its own FSH, and luteinizing hormone (LH) to make estrogen go up. FSH and LH are the naturally occurring ovarian stimulants and are also the same hormones found in the stimming drugs.

You will have to ask the clinic why they have chosen to use Clomid this particular time and about your protocol.

I hope I am making sense?
Take care.