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  • "pennyqueen" started this thread

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Friday, August 24th 2012, 5:43pm

Help - would another infusion help increase HCG levels?

Hi lades,

I'm writing in desperation really.

This is my 7th cycle - first with Intralipids infusion, clexane, predisiolne, gestone...

It's two weeks today since ET - a 3 day transfer. I tested postive on Sunday (v.early) so had bloods taken on Wednesday and again today. Unfortunately my first level was 28 and today its only 31 so they are not doubling as they should.

I've had my bloods done at a local clinic as I've previously had 4 chemical pg's - so wanted to peace of mind.

I'll be calling Care tomorrow to update them, but just wondered if in anyone's experience another Intralipids infusion would help??

I was due to have one if it was a bfp - but I'm not sure what they will suggest due to the levels. My local clinic suggested they should be 100 today.

Has anyone been in a similar position - should I push for an infusion if Care don't offer it? Any other meds that would help?

Thanks for any replies, this was my final try so I'm desperate and willing to do anything to hang on to this LO.

PQ xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

Maria72

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Saturday, August 25th 2012, 8:47am

Hunni I'm really sorry you are going through this :hugs:

Unfortunately if the HCGs aren't growing there is nothing much the doctor can do. Call the clinic asap and see what they say, they will know better than any of us on here.
:xxx:

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Saturday, August 25th 2012, 9:33am

Hi Pennyqueen, just saw your post and hoping clinic says something helpful. xfingers xfingers xfingers xfingers

  • "pennyqueen" started this thread

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Saturday, August 25th 2012, 12:35pm

Thanks for your replies Ladies.

I called Care today as it was my official OTD.

apparrently the infusion last 6-8 weeks so I'm still covered by that, and they suggest not having another until I've had another HCG test taken - the earliest will be Tuesday due to the bank holiday.

So more waiting...

Thanks for your kind replies xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

chatterbox

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Sunday, August 26th 2012, 11:14pm

I know of someone here of fz (but I cannot remember who! Sorry) who's numbers weren't great & getting who had a further IVig infusion & their numbers then continued to rise as they should. But I think these cases are few and far between.
I know intralipids can last up to 6 wks but the paperwork they send with the IL pack says you can have them every 4 weeks if necessary.

I hot my GP to prescribe extra as I was a bit paranoid. Don't be afraid to ask for more hun.

Xxx

Me 40 DH 35 TTC 10yr
peritoneal mesothelioma, cystectomy 97 & 00
peritonectomy, lost both tubes & most of left ovary Aug 07


Dec 07 BFP b/ov m/c 9.6wk
July 08 BFN
Dec 08 BFP b/ov m/c 9.6wk

July 09 BFN
Nov 09 BFP 2 x sacs 1 b/o 1 no hrtbt m/c 9.2wk
May10 BFP at 8+4 m/mc @10wk scan ERPC

Found: High NK cells, DQ Alpha match, LAD neg & PAI-1 pos...

NOV 2010 - Immune IVF at CARE Manchester
:BFP: [zx076] :girl: born 25/8/11

OCT 2012 - Immune IVF at CARE Manchester
:BFP: [zx076] :boy: born 24/6/13

  • "pennyqueen" started this thread

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6

Monday, August 27th 2012, 6:52pm

Hi Chatterbox,

Thanks for your reply, it gives me a little hope but I know my chances are slim. I'm hoping to have another HCG test on Wednesday and if its still positive an intrilipid infusion on Friday...

Just have everything crossed that this LO sticks tight xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

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Monday, August 27th 2012, 8:46pm

xfingers

Wardie

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8

Friday, August 31st 2012, 7:30pm

How are you honey? Xxx

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Friday, August 31st 2012, 10:05pm

Hi Wardie,

Hope you're ok - noticed you're on the road again - everything crossed for you with that :thumbsup:

Sadly, its not good news for me. Had another blood test on Wednesday and the levels are still not rising as they should - they'd only gone up by 3. Had they doubled at all I'd have pushed for another infusion, but as it was nothing was happening so I was advised to stop the meds and wait for AF. Unfortunately she hasn't made an appearance yet, so I'm still in limbo waiting for that to happen (and secretely wishing it wouldn't & for a miracle to occur!)

It's horrid knowing its going to happen - but I guess at least now it puts a line in the sand.

God know whats I'll do next - but suspect getting very drunk may come into it lol!!

xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

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Saturday, September 1st 2012, 8:41am

I'm sorry :hugs:

Wardie

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Saturday, September 1st 2012, 12:20pm

Oh honey I am so very sorry. Life really is so very cruel at times.

Thinking of you sweetie :hugs:

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Saturday, September 1st 2012, 7:39pm

Are immunulogy protocols different depending on the clinic?

Thanks Ladies, I'm still in limbo land which is frustrating - no idea when AF will show up!

Maria & the other immune ladies - can I ask you if in your experience that all immune protocols are the same? I'm just wondering if there is a difference between the likes of what Care offer and ARGC?
I know everyone's protocol will be different, but I was found to have elevated NK levels and was given an intralipid infusion, aspirin (til EC), steriods, clexane, prontagest and prognova.

I know you cant comment on specifics, but I just wondered if other clinics and Dr.G followed different protocols? I guess I just want to make sure i've covered all the bases before moving on.
I appear to be able to get pregnant, but just can't keep it...

Thanks in advance,
PQ xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

gemmab

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Saturday, September 1st 2012, 7:56pm

Unfortunately I can't answer your questions but just wanted to say how sorry I am this has happened again.x

ICSI 1 Apr 08-m/c 9.5.8
FETJul 08-BFN
ICSI 2 Dec 08 (ES) -I'm a mummy Kaynan arrived 19.8.09! :heart:
ICSI 3 Dec 10 (ES) -BFN
FET Mar 11- BFP- M/C ;(
ICSI 4 (ES) -:BFP: 1.7.11 Cobi arrived 09.03.12 [zx160]
Egg donation Aug 2012 BFN for recipient- gutted
Egg donation Dec 2012 Recipient :BFP:
Egg donation 27.05.2013- not great - please pray for the recipient :dust:





Maria72

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Saturday, September 1st 2012, 7:58pm

Hi PQ,

I think the clinics' protocols are slightly different from each other. For example the Argc prefers IVIGs to intralipids, dr Gorgy does the lit and the hidden chlamydia test, etc. Aspirin, progesterone, clexane and steroids seem common, but the brands of steroids can differ. Also the actual stage in the cycle when they give you drugs may change. For example I was given most the drugs (except the progesterone and clexane) more or less from the start. I was also given Clomid as well as the stimming drugs, others were given Viagra.
I had my cycle at the Argc and they will taylor the drugs to your blood tests and your specific case. Ladies on the same cycle will have totally different protocols, depending on hormones and immune profiles.
For my case I took humira first, then during stimming fostimon or merional (depending on the hormones blood test on the day), Clomid, aspirin, cetrotide, clexane and a steroid, buti can't remember the name (not prendisolone it starts with d,can't remember to save my life!). I had lots of different tyoes of elevated Nkcells and elevated cytokines.

They are slightly different cos none of this stuff has been tested properly so the consultants do a bit of informed guessing.
Even though I saw a scientific paper the other day talking about this stuff so maybe we will soon have some proper testing. And some answers...

Lots of love x

louise78

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Saturday, September 1st 2012, 8:48pm

I'm sorry to hear that pq :hugs:

My immune protocol was very similar to yours (mine was care Nottingham) I think all my drugs were the same as I have raised nk cells too. I hope you get some answers soon. Xx
6x cycles of clomid bfn
2X iui bfn
1x ivf - identical triplets - miscarried triplet at 9 weeks, lost my other two beautiful boys at 23 weeks - passed away shortly after birth 17th June 2010.
4x FET 1 early loss
1 natural early loss.
2011 Nov immune cycle FET bfn
2012 Jan immune cycle ivf bfp baby7 Ds arrived safely 1/10/12 : D
2013 Aug immune cycle FET bfp confirmed miscarriage at 8 weeks
2014 Jan immune cycle bfn
2014 April immune cycle bfn.
2014 July fet bfp ❤️ seen at 7,9 and 11 weeks

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Saturday, September 1st 2012, 10:22pm

I am so sorry Pennyqueen and the limbo you are in must be difficult. I am thinking of you.

love, Rianon

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Saturday, September 1st 2012, 10:59pm

Thanks Gemma, thats kind of you x

Louise - My last txt was with Care Nottingham aswell - probably why they were the same meds! I guess they must have a standard protocol they follow. Really pleased it worked for you x

Maria - thanks, you're informative as ever. I'm really in a quandry as to what to do next. We have a follow up consultation booked for early October so I'll be interested to see what they say - but from what I know they have given me all they offer, so I don't think there is a alternative protocol as such.

I suppose, what I'm wondering is if I should give ARGC or Dr G (are they at the same place?) a go or if I just need to accept my fate. I so wish we could have a crystal ball and it would make this rollercoaster so much easier.. or failing that some scentific answers Maria!

Thanks xxx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

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Sunday, September 2nd 2012, 7:00am

Dear PQ,

I wish I had some answers for you, I really do, but I don't. Doctors and science can only help us a bit, some stuff, like implantation, they don't know really what makes it happen or how to make it happen. Embryology in another field where there is need of some more studing. It's not as straightforward. That's way there is the term 'unexplained' infertility. They don't know.

As far as clinics, Dr G used to work at the Argc, so they work in similiar ways. They are both in London. Both expensive.
Someone else will come along with some info on Dr G, as I haven't been to his clinic, soI am not 100% sure on what he does.
I must say I cannot fault the Argc, even if my ivf and iuis were all unsuccessful. The Argc success rates are brilliant. But it's a chaotic and strange place. There is lots of waiting because you can just turn up without an appointment (unless you want to see a consultant for a full consultation).You also always have to wait for Mr T to check your notes, and that can take ages as he checks everybody's notes and the people in the stimming phase have priority. You become their slave for the duration of the treatment and have to do what they say when they say it. A bit like a fertility bootcamp. But the treatment is tailored to you properly and if they decide you can have the treatment it means you have a good chance. I wish I had gone there earlier. Now it's too late for me.
Maybe have an appointment and see what you think. Mr T thinks out of the box and may have some good ideas. Bear in mind you won't speak to Mr T. He does only your last scan before ec, ET and reviews notes. But he's in the clinic 12 hours a day. The consultant you will speak to will just tell you what Mr T thinks. As I said it's a strange place. But they are good. And they are trying to improve their image, even though I don't think that's important. It's better to have good doctors and good results than a nice waiting room!

Take care and look after yourself xxx

This post has been edited 1 times, last edit by "Maria72" (Sep 2nd 2012, 7:01am)


Rico

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Sunday, September 2nd 2012, 2:13pm

PQ - so sorry this has happened!

Hope you do get some answers soon xx

My Diary

1 IVF/ICSI failed to fertilise May 10 :bawl:
2: IVF/ICSI October10 (BFN) :sniff:
3: IVF/ICSI Feb 11 - OMG a very cautious :BFP: :bawl: Another little soul lost M/C 7 weeks :bawl:
4: Full fresh ICSI/SSR/IVF Feb 12 xfingers :BFN: :tear:
5: :goodnews: IM Barcelona for DE Oct/Nov 13 - :BFP: :heart: seen many times :loony:
Our miracle is here bab22 30/6/14 :thumbsup2:

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Monday, September 3rd 2012, 8:55pm

Thanks Rico and Maria.

Maria, sadly I don't know your story but I was so sad to read that you felt you had gone to ARGC too late. I don't 'know' you but I have to say you come across as such a thoughtful and caring Lady - completely selfless as you always seem ready and willing to help so thank you for all your support.

However, I guess you can read my mind! I do wish someone could just give me the answers and take away the decision as to what to do next. I feel in a quandry as to what to do next. This was meant to be our last go - but its so much harder giving up on that dream than I thought. I suppose I really want someone to take that decision away from me and make it for me - or at least tell me if its worth while...

I know no one can, but I live in hope :rollseyes:

You're impression of ARGC raised a smile - fertility boot camp definitely sounds like an experience! I guess time will only tell me which route I will go at which point I will no doubt be back with more questions|!!

Thanks again for your help & support,

PQ xx
Never give up on your dreams...they do come true.
ICSI #8, Anna born 26/2/14....the most amazing gift in the world x

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Monday, September 3rd 2012, 9:00pm

PQ,
You are right you will have to make that decision. BUT have some me time first and recover from this treatment and mc, then you can take action. Maybe read around clinic reviews, phone clinics etc until you can make that decision.
Unfortunately my story is long, too long probably and now it's too late to carry on with my own eggs.
Take care and look after yourself xxxxx

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