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Nick

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  • "Nick" started this thread

Posts: 1

Reg: Sep 20th 2011

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1

Tuesday, September 20th 2011, 6:52pm

Known researches on the effect of PGD on the newly born...

Hello everyone.

I am new to this forum (just found it while did some research on IVF/PGD on the web).
Let me start by saying that I think that this medium is so important and gives a lot of hope to people who seek information or just some encouraging words.

My wife and I are considering undergoing the IVF/PGD treatment due to the fact that I have a BRCA2 mutation that we do not want to pass on (we still don't have any children).
What worries us (I would be happy to hear your thoughts on this topic) is the fact that not so many children were born following the IVF/PGD procedure and it is still unknown what effects
will the process have on the newborn babies.
When I say "not so many children were born" I am saying this in comparison with the number of children born only via IVF.
We talked to several doctors who are specializing in the IVF/PGD field and they all say that there isn't enough data.

I wanted to know if any of you know anything about this concern and what is your opinion on the subject.

Sincerely,
Nick

Posts: 882

Reg: Dec 25th 2009

Location: London

Children: One Angel son 15.5.11 and a Rainbow baby son 13.10.12

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Tuesday, September 20th 2011, 7:42pm

Hello Nick,

Welcome! You'll get loads of information here.

If you'd like information on research, the best thing I think I can suggest is the ESHRE PGD Consortium data collections. They are research papers put together by specialists in PGD who are also part of the European Society of Human Reproduction and Embryology group. They collect data on all PGD cycles that take place in Europe and so have the widest amount of information available. A quick web search should bring up the papers I'm talking about, and then you can read at your leisure.

Essentially, they've not really noted a difference in health between babies born after PGD and babies born after normal ICSI treatment. The cells they test never go back into the embryo, so essentially the embryo 'loses' one or two cells from it's total number (about 25% total mass). Embryos that are frozen and thawed for future treatment with routine IVF or ICSI cycles can lose up to 50% of their cells and still create a healthy pregnancy and baby, so I guess it's similar to that if you think about it (and lots of babies have been born following this procedure). There are a good number of ladies on here who, following PGD treatment, have very healthy children running around, and I'm sure you'll get to know them soon enough. PGD provides a wonderful opportunity for people like us.

It's definitely a good idea to research anything you're thinking of undertaking, so feel free to ask away and bounce any ideas or concerns around. I hope I've helped a little, if you do decide to go down the PGD route, I wish you a smooth straightforward journey!
Hopeful2010
1 fresh + 1 FET PGD
1 angel in heaven, 1 here

Posts: 1,193

Reg: May 30th 2010

Thanks: 107 / 11

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Wednesday, September 21st 2011, 10:20pm

Hi Nick,

I am sorry you have to consider PGD it can be very scary with conditions like BRCA2 mutation where there is no telling how severe it will turn out for the child (if inherited). My husband and I did PGD and are now the proud parents of a little girl. I am convinced PGD does not carry any additional risks to ICSI as the only difference is the cell biopsy where they take 1 or 2 cells out of the 8-cell embryo. However at that stage the cells haven't specialised yet they will just divide again and make up for it.

Our little girl has 10 fingers and 10 toes so nothing seems to be missing :-)

Warm wishes,
Rianon

CAT12

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Reg: Aug 28th 2012

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Monday, February 25th 2013, 6:21pm

Did any of you read the study in mice? Do you think it has any merit? The last study on children born via pgd suggested no adverse effects to other children born via ivf but the mouse study rattled me....I'm a worrier by nature xx

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Thursday, February 28th 2013, 2:55am

I'm a worrier too! But mice is still a long way off from humans even a lot of drugs work differently on them that's why in the pharmaceutical industry further trials are done with other animals and finally clinical trials with humans.

Haven't read the study though and not sure I want to now having two children via PGD there is no turning back :-)
xx Rianon

CAT12

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Reg: Aug 28th 2012

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Thursday, February 28th 2013, 6:35am

Hello thank you for your reply. you're absolutely right mice are different to humans hence why cures for some diseases work in them but not us. How lovely that you have two children by pgd what a blessing. x x

miamiamo

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Posts: 75

Reg: Aug 9th 2015

Location: Poland/Germany/GB

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Friday, August 21st 2015, 12:43pm

We talked to several doctors who are specializing in the IVF/PGD field and they all say that there isn't enough data.

I read the interview with one know professor, who says that there is not enough scientific data, that children born ifv/pgd will have any future health problems etc.

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