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honeyz

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Reg: Oct 13th 2009

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1

Monday, December 21st 2009, 12:18pm

anyone had a bfp with just steriods?

Hiya all I hope ur enjoying the snowy season were having. :winter:

I was just wondering if anyone with suspected immune issues but not had the test, got a bfp with just taking steriods alone and no other immune drugs? If so which steriod and which dosage?

thankyou
honeybee

Mavis

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Tuesday, December 22nd 2009, 3:46pm

Hi Honeybee,
I think Kara (kar1) had steroids and no other immune drugs. She was on quite a high dose:
prednisolone side effects
M
x

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10 years, 5 cycles, and 3 beautiful children.
My family is complete :heart: :heart: :heart:

honeyz

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3

Tuesday, December 22nd 2009, 4:22pm

thnx

Thnx Mavis ur so kind u reply to most pplz questions :cuddle
honeybee

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Tuesday, December 22nd 2009, 4:47pm

blowkiss

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Wednesday, December 23rd 2009, 10:11am

After two BFNs I asked my consultant to test for immune issues. He said there was no point testing because the drugs he would put me on were not harmful so I could take them even if I did not have immune issues so he could give them to me 'blind'. So I took 10mg of prednesoline (steroids) and 75mg of asprin daily. I'll never know if it was the drugs or just better luck but I got my BFP third time lucky.
Newly Wed

ICSI December 2008 - chemical pregnancy
ICSI May 2009 - BFN
FET September 2009 - BFP
Beautiful twin girls born 30 April 2010



honeyz

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6

Wednesday, December 23rd 2009, 10:55am

Thankyou soo much newlywed I wish u all the best with the pregnancy a bucket full of luck.
That was exactly what I wanted to hear.
Can you plz tell me when you started taking them and when you stopped and if you had any side effects, if so did they go away after u stopped?

thnx a billion x
honeybee

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7

Wednesday, December 23rd 2009, 1:58pm

Pleasure. I had FET and I can't remember exactly but think I started taking the pills around 5 days before ET. I took the prednesoline for about 8 weeks and I am still taking the asprin which I think I stop at about 32 weeks pregnant (as it thins the blood which can cause excessive bleeding during birth). I didn't have any specific side effects other than the general rotten effects of D/R and cyclogest.

Very best of luck.
Newly Wed

ICSI December 2008 - chemical pregnancy
ICSI May 2009 - BFN
FET September 2009 - BFP
Beautiful twin girls born 30 April 2010



honeyz

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8

Wednesday, December 23rd 2009, 5:43pm

newlywed

[zx127]
honeybee

chatterbox

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9

Monday, December 28th 2009, 9:52pm

Thanks for this ladies, I was just looking for the very same info myself!

As IVIg isn't offered many places, what major differences are there between steroids and IVIg tx???

xxx

Me 40 DH 35 TTC 10yr
peritoneal mesothelioma, cystectomy 97 & 00
peritonectomy, lost both tubes & most of left ovary Aug 07


Dec 07 BFP b/ov m/c 9.6wk
July 08 BFN
Dec 08 BFP b/ov m/c 9.6wk

July 09 BFN
Nov 09 BFP 2 x sacs 1 b/o 1 no hrtbt m/c 9.2wk
May10 BFP at 8+4 m/mc @10wk scan ERPC

Found: High NK cells, DQ Alpha match, LAD neg & PAI-1 pos...

NOV 2010 - Immune IVF at CARE Manchester
:BFP: [zx076] :girl: born 25/8/11

OCT 2012 - Immune IVF at CARE Manchester
:BFP: [zx076] :boy: born 24/6/13

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10

Tuesday, December 29th 2009, 10:12am

I don't know much about IVIg from personal experience but from what I have read it is a far more aggressive treatment than the very basic steroid treatment that I had, is not widely available and is very expensive. I know that lots of ladies have got their BFP after IVIg and will swear by it. I was very keen to explore the option with my consultant but he advised that it is an experimental, non-mainstream treatment and would not contemplate it (his view, not mine!). I was paying a fortune for personalised care from the head of the ACU and he largely did what I wanted, but he felt very strongly against IVIg. I trusted my consultant 100% and was prepared to accept this advice on my last cycle which was successful with the steroids and asprin. However, had it not been successful, I probably would have gone elsewhere to explore immunology issues and IVIg.

Good luck CB. I hope 2010 is your year!
Newly Wed

ICSI December 2008 - chemical pregnancy
ICSI May 2009 - BFN
FET September 2009 - BFP
Beautiful twin girls born 30 April 2010



chatterbox

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11

Tuesday, December 29th 2009, 1:07pm

Thanks for that hun. My consultants don't give it a huge thumbs up as it is largely still experimental. I think the cost and the travelling to London for it would make the whole IVIg thing totally prohibitive to us. So looks like steroids it is!

Me 40 DH 35 TTC 10yr
peritoneal mesothelioma, cystectomy 97 & 00
peritonectomy, lost both tubes & most of left ovary Aug 07


Dec 07 BFP b/ov m/c 9.6wk
July 08 BFN
Dec 08 BFP b/ov m/c 9.6wk

July 09 BFN
Nov 09 BFP 2 x sacs 1 b/o 1 no hrtbt m/c 9.2wk
May10 BFP at 8+4 m/mc @10wk scan ERPC

Found: High NK cells, DQ Alpha match, LAD neg & PAI-1 pos...

NOV 2010 - Immune IVF at CARE Manchester
:BFP: [zx076] :girl: born 25/8/11

OCT 2012 - Immune IVF at CARE Manchester
:BFP: [zx076] :boy: born 24/6/13

Mavis

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12

Tuesday, December 29th 2009, 1:27pm

IVIG is totally experimental, and costs the Earth... There isn't any decent evidence to support its use, partly because it is so expensive to run trials with.

I did have IVIG for my last cycle, but I also had steroids for the first time (and other meds too) so it is impossible to know what made a difference, or if any of it made a difference (maybe I just got 4th time lucky).

For what its worth, I am far more of a believer in steroids than I am in IVIG. We don't know much about the interaction between the immune system and an implanting embyro, but we know lots about steroids. They have been around for a long time and are extremely effective drugs. Unfortunately their use is limited for many conditions because of side effects when used long-term. However, the dose/duration of steroid treatment in IVF is much, much safer.

Chatterbox, if you wanted to change something for your next cycle, I think adding in steroids would be a good step if your consultant agrees. Clexane, baby aspirin, and gestone (instead or in addition to cyclogest) are also things that might help.
I hope you are doing ok, have been thinking of you lots :cuddle
M
x

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My family is complete :heart: :heart: :heart:

Maria72

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13

Tuesday, December 29th 2009, 1:34pm

I'm gonna have steroids and clexane for my next cycle and I was also wondering about these drugs. The consultant said it is not proven that they work but there is no harm in trying them. She was not keen on baby aspirin, as she said it can affect the follicles, if I remember correctly. I'm also taking the pill instead of d/r. I really don't know what's gonna happen cos it's the first cycle that i don't do the standard tx. Any further info would be great.
:xxx:

chatterbox

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14

Wednesday, December 30th 2009, 4:39pm

Thanks for your reply Mavis. I think its the only logical progression for us, everything else seemed to go so well last time. I think it's the differential we need in the next round of tx.
Maria I can't believe that your ready to go again. xfingers hun that 2010 is our year.

xxx

Me 40 DH 35 TTC 10yr
peritoneal mesothelioma, cystectomy 97 & 00
peritonectomy, lost both tubes & most of left ovary Aug 07


Dec 07 BFP b/ov m/c 9.6wk
July 08 BFN
Dec 08 BFP b/ov m/c 9.6wk

July 09 BFN
Nov 09 BFP 2 x sacs 1 b/o 1 no hrtbt m/c 9.2wk
May10 BFP at 8+4 m/mc @10wk scan ERPC

Found: High NK cells, DQ Alpha match, LAD neg & PAI-1 pos...

NOV 2010 - Immune IVF at CARE Manchester
:BFP: [zx076] :girl: born 25/8/11

OCT 2012 - Immune IVF at CARE Manchester
:BFP: [zx076] :boy: born 24/6/13

Posts: 1,642

Reg: Feb 24th 2009

Location: Sorrento - Italy

Children: 1 DD - 2005

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15

Saturday, January 2nd 2010, 12:14am

another option to look at is the intralipid infusion. It is used in a simular way to the ivig thing but a whole lot cheaper. I am at CARE in Nottingham and the cons there is very interested in immunology. The prednisolone is used to supress your immune system so is still an immunology treatment.... I really don't understand it at all, but since my dr does...I feel ok about it!! Good luck girls!

Jan 05:BFP:
2007 - 2010 - 7 x :BFN:
DD 5yrs Old - Time to [zx103]


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16

Monday, January 4th 2010, 1:07pm

Just thought i'd throw in my tuppence worth as it sounds like we're in the same boat.

I've had 2 m/c and so this time I told the cons I didnt want to go ahead with tx unless i knew we were trying something different. He said there was no need to test for immune issues as the drugs will be fine either way. So...I started baby aspirin on 28th dec. I am doing an FET this cycle and ET should be sometime around 10th jan. I will also be taking clexane right through until 36weeks and prednisolone until week 13. That's if I get my BFP of course. Sorry, WHEN I get my BFP!! xfingers

All the best

nic xxxxxxxxxxxx
NicPic :P


May09 BFP m/c 6wks
Aug09 BFP m/c 5wks
Jan10 BFN
Apr10 BFP mm/c 7wks
Oct10 BFP mm/c 10wks
Feb11 immune issues discovered
Feb11 BFP m/c 5wks
May 11 FET cancelled due to abnormal growth in womb
Jun 11 hysteroscopy

honeyz

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17

Sunday, January 10th 2010, 9:28pm

nic pic

Good luck nic pic keep us posted :thumbup:
honeybee

honeyz

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18

Sunday, January 10th 2010, 9:53pm

I guess judging by the fact that not that many ppl have responded I guess it means that maybe there arnt that many success stories for women who have got their bfp's with just steriods?
:?: ANYONE
honeybee

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19

Monday, March 1st 2010, 1:22pm

I got 5th time lucky taking prednisolone and baby aspirin only!

kar1

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Wednesday, March 3rd 2010, 2:03pm

hiya all

im a steriod success, i took 20mg a day from et (day 2) and 20mg of clexane from day 8 of stimms which went up to 40mg a day from fetal heart beat
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

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Reg: Jun 1st 2010

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21

Saturday, June 12th 2010, 9:51am

Hi everyone and Newly wed,

the more i read the more confused i'm getting. Newly said:

Quoted

don't know much about IVIg from personal experience but from what I have read it is a far more aggressive treatment than the very basic steroid treatment that I had


I was told quite opposite. My drs were strictly against steroids. At the same time, they approve IVIG as harmless nad helpful.
I had IVIG for 4 months (till aprile),nothing happened, one month off and then got pregnant. I'm 5 w.now and just the othe day had the IVIG again. No steroids envolved!

If this ends up badly, I probably will regret not taking them.

It's driving me crazy all this, don't know what to do!

BraveGirl

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22

Sunday, June 13th 2010, 6:02pm

hi there

sorry to be a bit of a killjoy but please can ladies be very very very careful taking aspirin.

It not always safe i pregnancy as it crosses the placenta and thins the baby's blood. If you need a blood thinner then you should be prescribed clexane or something that does not cross. Please speak to your doctor before taking drugs without checking first.
IVF 1 :BFP: baby5 in heaven 6 weeks
IVF 5 :BFP: Immune protocol Care Sheffield
Oscar Miles arrived 15 April 2011 weighing 6lbs 14oz
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