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  • "toffeelady08" started this thread

Posts: 93

Reg: Dec 2nd 2009

Location: kent

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1

Thursday, September 10th 2009, 2:38pm

ICSI and anti sperm antibodies

Hi,

Just looking for some advice hopefully....

Due to start first ICSI next month, DH has anti sperm antibodies.

Can anyone give any tips or advice on any preparation that could help us?

Thanks



1st ICSI Nov 09 MM/C 11 weeks :sniff:

FET April 10

:BFP: :sticky:

Our beautiful daughter Holly Mae arrived 31st December 2010

Posts: 2,505

Reg: May 2nd 2007

Children: A boy and a girl, both living in London

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2

Thursday, September 10th 2009, 2:58pm

RE: ICSI and anti sperm antibodies

Around 10% of all men have some degree of anti-sperm antibodies in the seminal plasma and on their sperm. This is an autoimmune disease in the same way that asthma and rheumatoid arthritis are immune diseases. Sperm antibody reduces male fertility by coating the sperm with antibody protein which causes the sperm to stick together (agglutinate) in the semen, imparing their ability to swim into cervical mucus. Also the antibody coating is detected by the cervical mucus which inhibits these coated sperm from swimming normally through the mucus, and they become immobilised instead.

The impact that sperm antibodies make on an individual's fertility is dependent on the level of antibody and the degree to which the sperm are agglutinated or coated with antibody. The total number of sperm is also a factor as the more sperm there are then the more thinly spread is the antibody and the more chance there is of some sperm remainng free of antibody. A good sperm motility also helps.

Whilst steroids can and are sometimes used to treat this situation, these are potent drugs to have to take, and perhaps for a long time, and the benefits are very variable. Frequent ejaculation will increase motility and also reduce the degree of coating, as the coating tends to go on during the sperms' storage in the epididimis prior to ejaculation.

Ensuring that the female partner is maximally fertile helps in making the most use of the sperm, and ICSI enables easier contact between sperm and egg and is another approach to use.

Paul

become stThe impact that they have on male fertility depends upon the i
Fertility Scientist and Andrologist
Fertility Counsellor, Holistic Therapist and Hypnotherapist
Providing Fertility Information, Assessment and Enhancement.
Natural family planning teacher.

  • "toffeelady08" started this thread

Posts: 93

Reg: Dec 2nd 2009

Location: kent

  • Send private message

3

Thursday, September 10th 2009, 4:12pm

RE: ICSI and anti sperm antibodies

Thank you so much for your reply !

It has been a very useful and informative read.

In relation to what you said about the sperms motility...what does this mean and how can you improve this?



1st ICSI Nov 09 MM/C 11 weeks :sniff:

FET April 10

:BFP: :sticky:

Our beautiful daughter Holly Mae arrived 31st December 2010

Posts: 2,505

Reg: May 2nd 2007

Children: A boy and a girl, both living in London

  • Send private message

4

Thursday, September 10th 2009, 7:35pm

RE: ICSI and anti sperm antibodies

Hi,

Regular ejaculation every 2-3 days is the starting point, this will maximise sperm quality right from the start.

Zonc can improve sperm motility also as this metal is part of the enzyme that makes sperm active. Zincomed or Solvazinc are the prescribably products but talk to your pharmacist about what is available. Then DH takes twice the suggested dose for three months then reduces to the official dose, It may take up to 4/5 months before you see the benefits (if any), if there are stay on this dose. Reducing smoking and alcohol helps, and anything that might be overheating the testicles - over weight, tight underpants, too hot/too frequent baths, sitting down too much, log distance driving or cycling - these can all raise testicular temperature enough to decrease sperm production and quality.

Paul
Fertility Scientist and Andrologist
Fertility Counsellor, Holistic Therapist and Hypnotherapist
Providing Fertility Information, Assessment and Enhancement.
Natural family planning teacher.




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