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LKFowler

Newbie

  • "LKFowler" started this thread

Posts: 20

Reg: Sep 6th 2008

Location: Liverpool

Children: Baby Girl born March 2010 - natural conception 2 months after IVF - miracle!

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Monday, September 8th 2008, 2:32pm

High FSH and Prolactin

Hi, please bear with me i'm new to this and dont want to sound stupid but, I just had my results and was told I had a high fsh level of 13 and also a high level of prolactin. What does this mean in real terms? As i understand it, high fsh means my eggs are losing their potential to create a baby, and high prolactin means i might not be producing eggs, does anyone know if this is right? Does this mean i have even less chance of having a baby because of both high results, can anything be done for me? Any advice or information would be greatly appreciated as i'm worried and confused, thanks xx
Kate 33 (High FSH + Low AMH 5) DH 39
IVF #1 April 09 BFN :bawl:
BFP Naturally May 09 :happy:

IVF #2 March 12 :2ww

Eeyore

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Monday, September 8th 2008, 2:44pm

Hi there

Welcome!

We have lots of threads which I am sure will help - plus I have copied a post from one of our members below which really explains everything

xx

Prolactin

FSH levels rising

LH/FSH question

Endo& High FSH

In panic mode............

Fear of early menopause

fsh levels

Confused about FSH levels

Advice please... FSH LEVELS

help what good fsh level

FSH levels???

AMH / FSH - results and expectations

Quoted

Originally posted by Paul Entwistle
Hi y'all,

FSH and LH are two of the various hormones released from the pituitary gland (in the front portion of the brain) and they are transported through the blood stream to the ovaries and to the testicles (but not usually in the same person). Here they stimulate follicle and egg developement (FSH) and egg release (LH), in the female; and sperm production in the male. These are called the target or end-organs for these hormones.

These end-organs in turn release chemicals and hormones which travel back to the pituitary to let the pituitary have some feedback as to their response to the LH and FSH. If the output of the end-organs drops then more FSH or LH is sent to them. In the female, increasing age causes the ovaries start to become resistant to stimulation and become less likely to ovulate, probably in part because there are fewer primordial (immature) follicles left/fewer eggs to be released. When the pituitary senses this reduced response it sends down even more FSH/LH to push them into working. So the levels of these hormones in the blood stream gradually rise with age as the poor old ovaries get pushed more and more - until they say nuff's enuff and stop working. There are several reasons for poor ovarian response but the result is the same, high FSH and LH.

Where the FSH/LH are very high in the woman then she is in the menopause or peri-menopause, with an ovarian failure either appropriate to her age, or she may have a premature menopause/ovarian failure. She has problem therefore and will probably respond poorly to ovulation induction including IVF, and may even have to resort to egg donation. Measuring these hormone levels is what's known as measuring the ovarian reserve, and is used as an indication of how near to/far from/far in to, the menopause the woman is. It is only an approximate guide and works best in assessing the response to IVF ovulation induction and less well in predicting future, naturally ttc chances.

So what are normal levels of FSH and LH? Opinions vary amongst the experts, surprise! surprise! The test must be done very early in the cycle as the levels rise through the first phase of the cycle (the "proliferative phase" you will remember - Wake up you at the back), and false values will be obtained. In women with reasonably regular cycles this means day 1,2,3 of the cycle; with very irregular or no cycles, it has to be just a guess; - and in men with cycles it becomes a totally different syndrome.

FSH and LH will rise slowly with age whilst still being within normal, and fertile levels. Any result therefore has to be considered along with the age of the woman, but values of 5 - 14 iu/L are normal for women under say 38 yrs. Values greater than 18 or so suggest possible approaching ovarian running down, and values greater than 25 predict reduced success with IVF, although natural pregnancies can still occur from occasional spontaneous ovulations, so don't give up trying. FSH can vary from month to month to a degree so get it repeated if the first result is high. However it is not clear what this means and which result is the most predictive. The most predictive value is from a series of FSH results say over an 18 month period. A faster than normal rise suggests a rapidly approaching problem.

LH levels have a less predictive value but are normally lower (or should be) - with 4 - 8 iu/L being normal but then rising as the menopause approaches. The two hormones usually rise in tandem as the ovaries wind down. However an exception is in polycystic ovarian disease or syndrome (PCOD or PCOS) where the LH rises to levels 2.5 - 4 times that of the FSH, the FSH usually remaining within normal limits.

For men the LH is not usually measured and I confess to having forgotten the usual range. Most importantly the FSH will be in excess of 12 - 15 iu/L in end-organ testicular failure. Where this level is normal, say values down to 3,4,5 iu, but with azoospermia, then a bilateral absence or blockage of the vasa is indicated ie an involuntary vasectomy and this should be investigated with ultrasound or dye instillation. Very low levels of FSH suggests secondary organ failure with the grand diagnostic title of hypogonadotrophic hypogonadism, which can be treated hormonally.

And finally - to complete the story:

The pituitary is not its own master. It is only the foreman or shift manager. Further over in the brain is the hypothalamus. This organ which is an important part of the brain's functioning - the executive director as it were- keeps an eye on the activity of the pituitary gland, giving it a poke if it is not doing its job properly, and holding back any over-enthusiasm. But the Top Dog - the chairman of the board of directors - is the unconscious mind. This ultimately determines what happens around the body. This is the agent that stops ovulation or sperm production when you are stressed, or acts to prevent conception where there are unresolved anxieties or issues from the past.

This is why I have used counselling and hypnothereapy for many years for fertility enhancement in my practice and this has been written up in various magazines and newspapers (see me for the references!).

Good luck

Paul
xxx





My journey has now ended. 6 babies in Heaven.



'It'll be all right in the end - if it isn't all right yet then it isn't the end!'





LKFowler

Newbie

  • "LKFowler" started this thread

Posts: 20

Reg: Sep 6th 2008

Location: Liverpool

Children: Baby Girl born March 2010 - natural conception 2 months after IVF - miracle!

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3

Monday, September 8th 2008, 3:49pm

Thanks, theres a lot of useful info there. I'm still not sure tho if there's anything that can be done, do you know what the next step will possibly be? Drugs? or will I need a donor? Got an appointment in Dec, but thats ages away.
Kate 33 (High FSH + Low AMH 5) DH 39
IVF #1 April 09 BFN :bawl:
BFP Naturally May 09 :happy:

IVF #2 March 12 :2ww

Pootle

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Posts: 7,082

Reg: Mar 31st 2007

Location: By the coast

Children: 2 beautiful girls.

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Monday, September 8th 2008, 4:49pm

Hello! No idea about prolactin - not even sure what it is but can talk about FSH til the cows come home!

13 isn't the end of the world. Mine was up to 17 before I had IVF and realistically it meant I was harder to stimulate.

Have you had just the one test - maybe have another, and definitely at the right time in your cycle?

It is a worrying time - one of the threads Eeyore has posted is mine - I went into total panic but found a clinic and consultant who didn't despair and am now 31 weeks pregnant. But try not to get too worried yet.

December seems a way off - perhaps ask if it would be possible to offer you a cancellation as a way of getting seen earlier?

x






My family is complete...I am grateful every day

DD1, natural miracle, 2005
DD2, IVF miracle, 2008


LKFowler

Newbie

  • "LKFowler" started this thread

Posts: 20

Reg: Sep 6th 2008

Location: Liverpool

Children: Baby Girl born March 2010 - natural conception 2 months after IVF - miracle!

  • Send private message

5

Monday, September 8th 2008, 6:27pm

Thanks, thats reassured me that there might still be a chance, will deffo try and get a cancellation appt b4 Dec, goodluck to you and hope it all goes well xx
Kate 33 (High FSH + Low AMH 5) DH 39
IVF #1 April 09 BFN :bawl:
BFP Naturally May 09 :happy:

IVF #2 March 12 :2ww




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