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  • "Cathie" started this thread

Posts: 1,321

Reg: Oct 2nd 2007

Location: Notinghamshire

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1

Tuesday, April 8th 2008, 7:12pm

Can anyone tell me about IVIG???

Hey ladies

Hoping there is someone who knows something about NK bloods & IVIG from personal experience?? I have read lots of links and previous FZ threads on the topic, but would love to hear from anyone thats recently had it etc??

Cheers gang, need the help with information please!!!!

C
xxx
Cathie

Proud mum to Eric after 3 years TCC!!!

This post has been edited 1 times, last edit by "Cathie" (Apr 8th 2008, 7:52pm)


  • "alaskadas" is no longer a member of FZ

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Tuesday, April 8th 2008, 9:38pm

Thats a good question. I have no clue...
Is there anyone out there that could help us???

A.

Eeyore

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Tuesday, April 8th 2008, 9:58pm

I can't see any of the girls online who have had this, so have found an old post by KSKI which may help?

Quoted

Originally posted by kski
The use of IVIG was pioneered by the Sher clinics in USa and bought to the Uk by Mr Taranisi at ARGC _

There is some dispute over its effectiveness -
but to summarise - It works on the principlle that the uterine environmen may be hostile to the embryo - similar to the way a body may reject a kidney - so Ladies with a heightened Inmmune system - Thyroid problems and others mentioned below - may find certain NKs higher - hence the embryo cannot establish.

The tests are performed in Chicago - and they screen a range of about 15 factors - as shown - even within NKs - you have differnet derivatives of cells -

The treatment is to use an Intravenus Immuno globulin drip which dilutes the NK cells - and in theory makes you less likely to reject the embryo -

One can question the safety - but the proceedure has been used intransplants for 30 years now -
Equally - ( anita Roddick ) one could question the safety of Blood transfusions - but that goes unremarked

I have included alink -

Given the frontier treatment - I doubt whether a funding body would underwrite treatment for an elective IVF cycle -
It is hard enough to get them to pay for normal IVF ....

Hope this helps

k




MIL offers state of the art immunologic testing, which has shown to be useful in the diagnosis and management of recurrent pregnancy loss in affected couples. Such tests include

antiphospholipid antibody (APA) panel,
antinuclear antibody (ANA) panel,
antithyroid antibody panel,
embryotoxicity assay,
reproductive immunophenotype,
natural killer (NK) cell assay,
immunoglobulin panel,
anti-IgA,
coagulation assays,
lupus-like anticoagulant,
activated partial thromboplastin time,
protime,
homocystinemia,
antithrombin III,
factor V von Leiden
inhibin B
All tests can be obtained through MIL by calling (312) 274-1928.

Top
Treatment for Recurrent Miscarriage
Treatment for repeat pregnancy loss depends on the underlying causes. When an immunologic cause of recurrent miscarriage is diagnosed, immunotherapy is available through SIRM. Treatments include

aspirin
heparin
prednisone
IVIg
intralipid
The first controlled clinical trial in the United States was performed using intravenous immunoglobulin (IVIg) for the treatment of recurrent miscarriage. The results of that clinical trial established the efficacy of IVIg for treatment of some cases of recurrent pregnancy loss. More than 300 pregnancies have thus far been established with this treatment. IVIg has been successfully used for treatment of recurrent miscarriage associated with autoantibodies, an elevated percentage of circulating natural killer cells and embryotoxins, as well as for unexplained recurrent pregnancy loss.

http://www.haveababy.com/infertility/ind…=local&page=rpl

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Eeyore

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4

Tuesday, April 8th 2008, 10:04pm

Found a thread by Tinks, she had the same treatment at the same stage as you and now has a gorgeous baby boy

HCG Levels

If you type IVIG into the search and 'show as posts' you will find all of her posts about it

x


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My journey has now ended. 6 babies in Heaven.



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kar1

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5

Tuesday, April 8th 2008, 10:07pm

TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

  • "Cathie" started this thread

Posts: 1,321

Reg: Oct 2nd 2007

Location: Notinghamshire

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6

Wednesday, April 9th 2008, 8:03am

Thanks gang, much appreciated

C
xxx
Cathie

Proud mum to Eric after 3 years TCC!!!

Posts: 1,363

Reg: Feb 16th 2008

Location: Surrey

Children: TTC child no 1 hoping for BFP 08

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7

Wednesday, April 9th 2008, 3:27pm

:bye: Cathie,

Sorry I can't offer any answers but Im glad you have had some good replies. Just didn't want to read and run.

Take care blowkiss

nickate

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Wednesday, April 9th 2008, 4:04pm

Had the NK killer test done where they took a swab of my womb (did not hurt) and was clear, saw the blood flow vein too.

I have read that it should be done whilst pregnant (mine wasnt), but Liverpools womens hospital have a pregnancy immunology lab run by Dr Quinby. Your local hospital (private or NHS) may have the same.

Not much help, but you can try some hospitals around you, your GP should know of one if there is one.

Crossing my fingers Katex
Katex jilly bab13

  • "Cathie" started this thread

Posts: 1,321

Reg: Oct 2nd 2007

Location: Notinghamshire

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Wednesday, April 9th 2008, 6:22pm

Have had the tests done at my clinic today and they're on the way to Chicago for analysis, so hoping to get the all clear sometime next week.... Is all very new, but the research I have done on here, and LOADS of other sites etc is that there is a sound case that the NK cells do exist and can effect fertility and successful pregnancy, and also that IVIG treatment is normally very sucessful in treating it.

So glad my clinic have said is an option, and waiting with baited breathe!!

Also cheaper that I thought for the tests..... BONUS!!!!
Cathie

Proud mum to Eric after 3 years TCC!!!

Posts: 2,026

Reg: Jul 21st 2007

Location: Kent

Children: Baby boy Brennan...born 23rd April 09

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10

Wednesday, April 9th 2008, 6:34pm

How worrying for you Cathie...hope all turns out well,sending you hugs x
ME 33 DH 36
TTC 4 YEARS
2006 TUBAL ECTOPIC
2007 IVF CORNUAL ECTOPIC
2008 FET BFP! TWINS BUT LOST ONE AT 7W3D

BRENNAN MATTHEW WATTS BORN VIA C SECTION ON 23RD APRIL 2009
OUR DREAM HAS COME TRUE WE GOT THERE IN THE END :happy:






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