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mrs_smiff

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Posts: 5,387

Reg: Jan 10th 2007

Location: Somerset

Children: 5 kids aged 21,18,14,13 and a little miracle born April 09

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Friday, November 23rd 2007, 11:35am

Male chromosome testing

My Dh has been told he needs a blood test for 'chromosome testing'. Can anyone tell me what they look for in these tests and what the implications could be? I can't find anything anywhere about it, only some vague referrals to it.
Me 35,DH 36 (Severe Oligospermia.).
4th ICSI :BFP:
I have 4 lovely big kids
Thomas Derren (Thom) July 1990
Luke Benjamin August 1993
Harley John Oliver June 1997
Alexandria Aimee Jay (Alex) July 1998
Lochlan Cassius James April 2009 (4th attempt at ICSI)



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Reg: Jul 15th 2007

Location: south west

Children: if only!

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Friday, November 23rd 2007, 12:19pm

RE: Male chromosome testing

my understanding is that they will be looking to rule out:

abnormalities in the number of chromosomes which are associated with the failure of affected sperm to produce viable embryos/healthy babies e.g.,

having an extra X chromosome - 'klinefelter syndrome' (which is associated with failure of the embryo to develop, increased risk of miscarriage, birth defects and developmental difficulties)

Y chromosome micro deletion (which is associated with either total failure to fertilise or increased risk of male infertility in the offspring)

chromosomal translocation (which can result in extra or missing genes which can sometimes to be totally benign or sometimes result in failure to fertilise or birth defects)

cystic fibrosis (increased risk of the offspring having cystic fibrosis, being a carrier of cystic fibrosis or being infertile)

So the implication of the test would ideally be that your DH is clear of known genetic abnormalities which would are linked to failure to fertilise/miscarriage/birth defect/developmental difficulties.

Hope this is some help... although I haven't found a good source of info on the net which puts everything together for you.

Mousie x

kar1

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Friday, November 23rd 2007, 3:58pm

Chromosomal analysis or karyotype: parents
What are chromosomes?
Chromosomes carry the genetic information for each individual. Everyone has 23 pairs of chromosomes, making 46 in all. All but one pair are identical in men and women. The 23rd pair ¨C the sex chromosomes ¨C decide the individual's gender and are therefore different. Men normally have one X and one Y chromosome and women have two X chromosomes. A baby inherits half of its chromosomes from its mother and half from its father.

How can chromosomes cause a problem?
About half of all miscarriages occur as a result of a chromosomal abnormality in the baby or fetus. In most cases where this abnormality causes miscarriage, the problem is not passed on from a parent, but happens when the egg and sperm meet, or early in the development of the fertilised egg.

Between three and five percent of couples with recurrent miscarriage have a problem with a chromosomal abnormality called a balanced translocation. In this situation, part of the information from one chromosome is replaced by that of another chromosome. Although this doesn't cause a problem to the affected parent, it can be passed on to the baby and cause an unbalanced translocation, where some genetic information is present twice and some is missing. This can lead to miscarriage.

The Miscarriage Association can provide a leaflet on request on balanced translocation.

Testing

Chromosomal analysis involves taking a blood test from both the man and the woman and sending the samples to a genetics laboratory. The results can take between four and six weeks to obtain, as the cells have to be specially processed before they can be examined under the microscope.

Treatment

There is no treatment which can alter the chromosomes in an individual if they are already abnormal. If the analysis shows that you or your partner carry an abnormality, then you will be offered specialist genetic counselling to give you more information and help you decide about future pregnancies.

i copied this for you hun, myself and dh had these done and it took 12 weeks for the results, its amazing when you look into all this and i know understand why they take so long as they really go through your blood spot by spot.

is your gp doing the test?
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

mrs_smiff

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  • "mrs_smiff" started this thread

Posts: 5,387

Reg: Jan 10th 2007

Location: Somerset

Children: 5 kids aged 21,18,14,13 and a little miracle born April 09

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4

Saturday, November 24th 2007, 12:26pm

Yeah the GP is doing the test which is great as I understand that it's quite expensive. Thanks for the info hun. I don't think we will have the results back by the time we start treatment which makes me wonder if there is any point in hurrying to get it done. Especially given DH's needle/hospital phobia. I might give the clinic a call on Monday and see what they say.
Me 35,DH 36 (Severe Oligospermia.).
4th ICSI :BFP:
I have 4 lovely big kids
Thomas Derren (Thom) July 1990
Luke Benjamin August 1993
Harley John Oliver June 1997
Alexandria Aimee Jay (Alex) July 1998
Lochlan Cassius James April 2009 (4th attempt at ICSI)



kar1

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Posts: 12,830

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5

Saturday, November 24th 2007, 12:29pm

we went for tx without having the results back!

after all if they did find something their isn;t a lot they can do....chances are all is fine though.

its great they are doing this after 2 cycles hun and your gp sounds brill
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

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