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  • "Pickles" started this thread

Posts: 769

Reg: Dec 30th 2007

Location: South London

Children: Was Lister

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1

Wednesday, May 21st 2008, 8:14pm

NK cells and IVIG

I've just got the results of my NK cells test (CD69) back and I've been told that I have a moderately high result of 25% - something like a killer rate. I think this means my likelihood of an immune reaction to implantation is above normal.

I was told that if I took a steroid after my EC that this figure would reduce to 14% and that if I opted for IVIG this would reduce to 8%, but this would cost £1500.

Has anyone taken this test and been given a moderately high rating. I'd be interested to learn about anyone experiences.

I've never been pregnant and on both ICSI cycles good grade embyros were put back without success.

Thanks
Pickles




4 ICSI - all BFN
Poor responder (6 eggs max on left ovary only)
High NK cells
Considering Egg Donation

Posts: 2,643

Reg: Feb 28th 2007

Location: Surrey

Children: Not yet

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Wednesday, May 21st 2008, 8:30pm

RE: NK cells and IVIG

Hi Pickles

I have read lots on IVIG, sorry I haven't experienced it myself. I have been given steroids in the past before and during pregnancy in case I had an immune issue, (my nk cells were normal) I believe they have a very good success rate. The steroid I was on was prednisalone. There was another lady on here who had high NK cells and under the same consultant as me took the steroids and now (after 3 m/c's) she has had a baby, so it worked wonders for her.

Back to IVIG, I don't believe there is much research out there on it and I do know its expensive and needs to be timed with your ICSI / IVF. I do know of someone who has had IVIG and went on to have a successful pregnancy after many failed implantations.

The Dr Alan Beer book goes into some detail about it, he also has a website, just google him.

Good luck
x
TTC naturally, five miscarriages 2006-2009, Immune issues

BLONDIE'S IMMUNOLOGY DIARY

kski

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Reg: Mar 26th 2006

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Thursday, May 22nd 2008, 10:36am

IVIG Info

Hi

if you type in IVIG to the search box - it will pull up some great threads on the subject and on the clinics, linking to some very good diary posts.


this is one from recall that has a post with specif info
Anyone got knowledge of NK cells?


if you have any other questions feel free to ask - we went down a similar path after 2 IVFs and 2 IUIs

hope it all is of some help
K
DAD to twins

  • "Pickles" started this thread

Posts: 769

Reg: Dec 30th 2007

Location: South London

Children: Was Lister

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4

Thursday, May 22nd 2008, 10:20pm

RE: IVIG Info

Many thanks Blondie and Ksi will pop details into the search engine and look up the book you recommended.

Yet another round of research - there's always something new to learn when on the IVF treadmill!




4 ICSI - all BFN
Poor responder (6 eggs max on left ovary only)
High NK cells
Considering Egg Donation

kar1

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Thursday, May 22nd 2008, 10:27pm

dr alan beer's book, is your baby body friendly a good read

i have read it back to front and i think of some treatment you need to make your own mind up

IVIG is bringing out the big guns and if you feel this is something you wana try you go for it, but if unsure try steriods first, dexemethasone is another steriod used and a favorite of late dr beer

good luck whatever you decide
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

  • "Pickles" started this thread

Posts: 769

Reg: Dec 30th 2007

Location: South London

Children: Was Lister

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6

Thursday, May 22nd 2008, 10:33pm

Cheers Kara. I'm still not sure what to do so will buy the book this weekend. I had that steroid you mentioned last time, but that was before I knew about my killer cell count.

It's a really hard call to make as it feels more emotional than logical.




4 ICSI - all BFN
Poor responder (6 eggs max on left ovary only)
High NK cells
Considering Egg Donation

kar1

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7

Thursday, May 22nd 2008, 10:37pm

are you at agrc?

was the blood taken from your arm or womb?

i have my own views on NK cells and haven't been tested at all....
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

  • "Pickles" started this thread

Posts: 769

Reg: Dec 30th 2007

Location: South London

Children: Was Lister

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8

Thursday, May 22nd 2008, 10:41pm

No the Lister and blood taken from the arm.

I'm not sure either. A lot of research has been done by one of the consultants at the centre but they were very cautious about giving me false hope on the results.

They fully admit that it's a new emerging area with little scientific evidence. At least the steroids have more science behind then. But then there's that nagging doubt that perhaps the new science will one day be proven.....It's a minefield.




4 ICSI - all BFN
Poor responder (6 eggs max on left ovary only)
High NK cells
Considering Egg Donation

kar1

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  • "kar1" is no longer a member of FZ

Posts: 12,830

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9

Thursday, May 22nd 2008, 10:44pm

you are so right , it is a minefield, i always say do what you feel you will have no regret over if the worst happens and it fails
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine




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