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  • "MelanieC" started this thread

Posts: 1,273

Reg: Mar 17th 2008

Location: Southampton

Children: One step daughter

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1

Sunday, April 27th 2008, 3:42pm

Zero fertilisation, can anyone help!

Hello!
Not been on since last Wednesday and e/c as had the awful phone call on Thursday morning. Out of the 12 eggs I had, 9 were mature enough, 3 fertilized abnormally and the other 6 didn't fertilize at all. Bawl
I have been struggling to come to terms with this, it is a massive blow. Although they were just eggs and sperm, they were part of us and we feel bereaved! I dont think I could feel worse if I had lost my own mother. The consultant and embryologist are baffled and haven't been able to give us any reasons or answers at all. DH's last sperm test showed 98% abnormal forms so they suggested ICSI for us. On Wednesday his count had gone up considerably but they didn't checked morphology as we were having ICSI. We are in total shock. We have wondered if the clinic cocked things up or used a junior embryologist or something? Also, the clinic had had a power cut the morning of my e/c and were running from a generator and we wondered if this could have affected things? I just cannot believe this has happened when in the beginning they gave us such a good chance of success, its just so unfair. I have a swollen pregnant looking belly which is making it harder. Life truly is a swear1 sometimes. They have suggested that next time we do half ICSI and half normal IVF, as with IVF the strongest breaks thru and this time the embryologist may have thought they got good ones but picked abnormal ones. I am just so scared it will happen again! They said the chance of this happening at all was 5%! Does anyone know if it is my eggs, what could be wrong with them? Can eggs be infertile or empty? All 12 of them?
Sorry to be the bearer of bad news, I didn't know whether to post this on here as I know how you are all trying to have PMA I didn't want to bring you down. Just feel very alone in this nd wondered if anyone has had a similar experience? Any help or advice would be greatly received.
:sadface:
xxx

First ICSI April 08 - 9 eggs, zero fertilisation :bawl:
2nd ICSI Sept 08 - 10 eggs, 100 % fertilisation ?( - BFN tho
Natural FET January 30th - BFN
NK Cells Test 22nd April - Result - Normal.
ICSI 3 - November - BFN



Michelem

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Sunday, April 27th 2008, 3:51pm

RE: Zero fertilisation, can anyone help!

Hi MelanieC


I'm sorry about your news, I can't help you but, I do want to send you a :hugs:
MNM

  • "bouncytigger" is no longer a member of FZ

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3

Sunday, April 27th 2008, 3:59pm

Oh Melanie.

I wondered where you'd been.. :hugs: I just don't know what to say..

I know when this happened to Julie, they said that ICSI might solve it, but you're saying you did ICSI??

Do you get a follow up appointment, I would go in armed with all the questions that you have and I know there is a section on here for follow up questions.. Initial & Follow Up Questions Once you have some answers, that will help you maybe to understand..

That might help you and it's might want to talk to Julie (Misshortly) if you feel able to..

I can only imagine what you're feeling at the moment and would also say, don't ever feel you can't post here - all of us are at different stages, but use the support and experience of everyone on here...

Thinking of you sweetie... I hope you get some other answers that help you..

blowkiss
ICSI number 5 - BFP!! :boy: :girl: arrived December 2010

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4

Sunday, April 27th 2008, 4:01pm

RE: Zero fertilisation, can anyone help!

Poor old you

One of the ivf experts will be able to help with some advice babes, just wanted to say i did the 50/50 ivf icsi thing and it worked a treat, but I must admit to get 0 fro 12 is damn bad luck

Sorry youre feeling rotton and do go back to the clinic and ask why again when its not so raw, or change them if youre unhappy

C
xx
Cathie

Proud mum to Eric after 3 years TCC!!!

gemmab

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Sunday, April 27th 2008, 4:01pm

Just to say I'm so sorry this has happened to you and I hope you get some answers.

blowkiss

ICSI 1 Apr 08-m/c 9.5.8
FETJul 08-BFN
ICSI 2 Dec 08 (ES) -I'm a mummy Kaynan arrived 19.8.09! :heart:
ICSI 3 Dec 10 (ES) -BFN
FET Mar 11- BFP- M/C ;(
ICSI 4 (ES) -:BFP: 1.7.11 Cobi arrived 09.03.12 [zx160]
Egg donation Aug 2012 BFN for recipient- gutted
Egg donation Dec 2012 Recipient :BFP:
Egg donation 27.05.2013- not great - please pray for the recipient :dust:





Peppa

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6

Sunday, April 27th 2008, 4:05pm

Oh no, i'm sorry to hear what's happened :hugs:




ICSI May 08 - BFP
Our beautiful baby girl was born February 2009
Jan 2010 natural BFP M/C 9 weeks
May 2011 - BFP
Baby boy born Jan 2012




Ros

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7

Sunday, April 27th 2008, 4:28pm

Really sorry it didn't work out Melanie x

After 5 years of endo surgery, clomid, 2 x MM/C, 2 x ICSI cycles and 1 PGD cycle,
beautiful twin girls born 8th Feb 2010, we are so grateful

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8

Sunday, April 27th 2008, 4:32pm

RE: Zero fertilisation, can anyone help!

Hi Melanie

I so sorry to hear what has happened, my heart really does go out to you.

Although I have no answers for you, I have been through a simular thing. This time last year we went private for our first attempt at IVF. I have blocked and damaged tubes and hubby has higher than average sperm count (something of which he is very proud of!!). Well everthing went fine and I produced 10 eggs all of which were of very good quality. Up untill then I had tried to remain very real in that I knew tx may not work, but when I produced the 10 eggs we where on top of the world. Unfortunatly 2 days later we also had the heart breaking news that none of the eggs had fertilzed.

One week later the consultant called me to inform me that everything had been infected with ecoli in the hospital. Please understand that I am not surgesting that this may of happened in your situation however please dont feel that you are alone in this crazy world. Not once had I been told that this was a posibility, however my ocnsultant said that this happends once a year in every hospital. Speaking to other specialist people no one has ever heard of this and I still feel I have no answers for what happend to us. The hospital will not take responcability but at the same time they would not treat us for any illness, hence I feel that that says it all really.

The consultant advsied us that next time we try to have half icsi and half ivf, as icsi reduces the chance of infection.

I really am truely sorry for what has happened to you and if you need to chat then please email me. Although Ive got no answers I conpletly understand you situation.

Both me and my husband felt exactly like you are surgesting in that we went through a greiving process. We are currenlty going through our second treatment and I am petrified that the same thing is going to happen again to us. ;(

Lots of love to you both
:cat:

1x IVF zero fert, 2x ICSI BFN, 1x FET BFN, 1x ICSI early loss

March 2010, FET , :BFP:, we have a little princess x

SarahV

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9

Sunday, April 27th 2008, 4:37pm

Mel, I wrote back to you the other page, but just writing here again - I really am very very sorry - it's just gutting.

I think you are right to want to understand more, maybe that can help you understand and move on and I think your consultant needs to help out more in that respect. I really can't help you other than say that I would be wanting to know more too.

I think half and half sounds like a good idea next time round (although I don't understand enough of the ins and outs), sometimes nature works these things out - and IVF is something different than last time. Also, just bare in mind this could be an unfortunate, one off - I pray it is

I'm really sorry honey, I really hope next time is perfect
.......


Mrs M

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Sunday, April 27th 2008, 5:26pm

Hi Melanie

I am so sorry - on out first cycle the swim-up sperm test didn't go as well on the day as they wanted so they suggested doing half IVF and half ICSI. Glad we did as the 9 IVF all failed to fertilise and 6 of the 9 ICSI did.

I would ask them what would have contributed to none working and why next time you would have half and half rather than all ICSI

sending you a :hugs: xxx

------------------------------
Me 33 DH 40, TTC 7+ yrs, unexplained infertility
3 x ICSI and 3 x natural FET with assisted hatching - all BFN :(
Our treatment journey has now ended

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Sunday, April 27th 2008, 6:24pm

Hi
I am sorry about your treatment ending the way it has. I had 29 eggs 21 were inj for icsi and only 7 fertislised. I know its not the same as we do have some embryos they did expect to get more. Some of the eggs were immature and some shattered during the icsi. I think that is due to my age. Hopefully this is a one off for you and next time everything will be fine.Try to stay positive and here is a :hug: for you :xxx3:


Me 45 DF 44
1 m/c 2004
1st ICSI BFP Mm/c 11 weeks 2008
4 ICSI x 4 BFN[/color
2 x DE cycle BFN
2x FET DE cycle BFN
1 x FET DE cycle BFP!!!!!!!


  • "MelanieC" started this thread

Posts: 1,273

Reg: Mar 17th 2008

Location: Southampton

Children: One step daughter

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12

Sunday, April 27th 2008, 7:02pm

Thanks for all your replies and all the support girls. We are just baffled, the ones of you that have had similar experiences seem to have gone on to have ICSI and all got embies. We had ICSI this time tho and got none which makes us feel like there is no other avenue for us apart from maybe donor eggs or sperm. I cannot understand why the consultant would suggest trying half next time with traditional IVF, its like going back on what they have said from the beginning! Why would IVF work over ICSI if there is a problem with DH's sperm?!! I have conceived before and DH has a 6 year old, could it be that we arent compatible on top of my blocked tubes and his poor morphology!!!

:hairout

First ICSI April 08 - 9 eggs, zero fertilisation :bawl:
2nd ICSI Sept 08 - 10 eggs, 100 % fertilisation ?( - BFN tho
Natural FET January 30th - BFN
NK Cells Test 22nd April - Result - Normal.
ICSI 3 - November - BFN



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Reg: Oct 10th 2007

Location: westmidlands

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Sunday, April 27th 2008, 7:58pm

oh hun.... i am so sorry and wish i had the answers ......i know what you mean about the grieving bit its dreadful.....i do hope you get your answers you need... i know it will be difficult for you but we are all her for you if you need us.

xxxxx


3 X FAILED IUI through 2007
1 X IVF April 2008 :BFP: mc in week 6 (my angels)
1 X FAILED Natural FET August 2008 using one embie that survived thaw
1 X FAILED IVF MARCH 2009
"The future belongs to those who believe in the beauty of their dreams"

:cat:

Duffymoon

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Sunday, April 27th 2008, 8:04pm

RE: Zero fertilisation, can anyone help!

Hi Melanie

First and foremost the biggest hug to you for what must have been some really tough days to get your head around this. :hugs:

I'm in shock that I'm reading again about this happening (as BouncyTigger said, MissShortly had no eggs fertilise as well last week).

In her case the consultant/embryologist are baffled and it sounds like you're not getting answers from yours either.

Reasons why eggs don't fertilise aren't always obvious but on reading your first post, it does look like it's the quality of your DH's sperm.

I've read of people who have had total fertilisation failure with IVF and then are advised to have ICSI, but I've not heard of it the other way round. That said, it's not going to do any harm trying 50/50 (IVF/ICSI) next time and I think if it was me, I'd go with that, just to feel like I'd tried both options. As you've just posted, to go from ICSI to IVF is not what normally happens but I don't think they would suggest this without good reason.

If you can find out what your DH's exact count was (in terms of morphology/motility etc) , it may be worth posting it on here 'Life in the Lab' - for all sperm questions! or PMing Sperm Scientist if you prefer to see if she has any expert advice on the liklihood of this working with IVF alone (i.e not ICSI).

I've had fertilisation issues myself so can empathise to a degree. Eggs do have different quality issues but most are visible to the embryologist and they would be able to tell this before fertilisation.

I'm sorry to say, but in some cases, IVF can be trial and error (at our expense!)......I'm on my 3rd try now and hoping and praying that my first two goes have given my clinic the information they need to progress this and fingers crossed, end up with much better fertilisation and quality of embryos.

I very much doubt that your clinic left a Junior embryologist in charge of your case, they have very high protocols to follow and I doubt as well that the power failing had a part to play either; they have generators for this very reason.

I know you must want answers (yesterday!) and I'm so very sorry that you are having to go through this painful time.

I really hope they can suggest "a reason" for this and make sure it doesn't happen again.

I'm sorry I can't be of more help Melanie. :cuddle

xxxx


4 x ICSI BFN
5th time :BFP:
:boy: :girl:




Ozzy

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Sunday, April 27th 2008, 8:08pm

Really sorry to hear your news Melanie :hugs:
Catherine



Me 37, PCO. DH 44, average!
IVF #1 April 08 abandoned (too many follies, risk of OHSS)
IVF #2 - BFN
IVF #3 - BFP 14/02/09


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Reg: Apr 14th 2008

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Children: 1 on the way Yiphee!

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Sunday, April 27th 2008, 9:04pm

Really really sorry to hear that Melanie! :sadface:

Kassi

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Reg: Apr 6th 2008

Location: leeds west yorkshire

Children: 1 daughter 14 this month

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Sunday, April 27th 2008, 9:18pm

Hi Melanie,

I know exactley how you are feeling, I did icsi, I had EC on friday 25th april at 930, thought I had maybe 4-5 follies, only managed to get 1 egg, devastated but tried to stay positive as it only takes the 1, received call at home about 345pm telling us egg was immature and nothing else to do, feel so gutted as like you I have conceived b4(daughter now 14years) feel so empty, but we have to keep our chins up, all I can say is hopefully next time for you.

Sending you loads of :hugs:

Laura
:xxx3:

becks

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Reg: Apr 17th 2008

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Children: DH has 2 teenage daughters

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Monday, April 28th 2008, 7:47pm

Hi Melanie

So sorry to read your news. If I were you I'd definitely get as many questions as you can written down, and go for a consultation, armed.

I don't know if your treatment was on NHS or private - but I really hope you are in a position to try again.

xx
Ist ICSI Apr 08 - :BFP:
M/C at 11wks :sadface:
FET Apr 09 - :BFN:
FET May 09 - :BFP:




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Reg: Feb 20th 2008

Location: New Zealand

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19

Tuesday, April 29th 2008, 8:33am

I am so sorry to hear your news...it is hard. Sometimes things don't work the way we want them to...we just have to be strong
:flowerbasket:

ali
Have completed....

1. 26km cross-country run Easter 2009
2. Half-marathon on 31st of May 2009
3. Half-marathon on 13th of September 2009
4. Half-marathon on 28th of November 2009

Next is high-country marathon on 13.3.2010

chatterbox

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Wednesday, April 30th 2008, 9:47am

So sorry to hear your news Mel.

xxx

Me 40 DH 35 TTC 10yr
peritoneal mesothelioma, cystectomy 97 & 00
peritonectomy, lost both tubes & most of left ovary Aug 07


Dec 07 BFP b/ov m/c 9.6wk
July 08 BFN
Dec 08 BFP b/ov m/c 9.6wk

July 09 BFN
Nov 09 BFP 2 x sacs 1 b/o 1 no hrtbt m/c 9.2wk
May10 BFP at 8+4 m/mc @10wk scan ERPC

Found: High NK cells, DQ Alpha match, LAD neg & PAI-1 pos...

NOV 2010 - Immune IVF at CARE Manchester
:BFP: [zx076] :girl: born 25/8/11

OCT 2012 - Immune IVF at CARE Manchester
:BFP: [zx076] :boy: born 24/6/13




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