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IVM

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  • "LFinn1964" started this thread

Posts: 11

Reg: Feb 24th 2006

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1

Wednesday, January 3rd 2007, 1:48pm

IVM

Saw an article in times online December 30 regarding IVM or In Vitro Maturation where they take the undeveloped eggs and develop them, get the sperm and then implant a fertilized embryo. They say this takes less drugs and is beter for the woman. Has anyone else heard of this and what are your thoughts?

Thanks

Lisa
LISA


Me 43 DH 49
Unexplained infertility

Ist IUI Feb 06 2 Follicles 16 and 18 14 mil sc BFN
2nd IUI June 06 2 Follices 18 and 23 28 mil sc BFN
3rd IUI August 06 I follice 19 19mil sc BFN


IVF Apr 07 stopped due to small follicles

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Reg: Oct 18th 2006

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2

Wednesday, January 3rd 2007, 2:40pm

I read something about this recently, but the only thing i remember about it other than what you have already said, is that it is more suitable to under 35's. No good for me then!!

Me 40, DH 42, TTC 16 yrs, Unexplained.
IVF 8/06 BFN
IVF 11/06 BFP - m/c @ 5+ wks
ICSI 12/07 BFN
4/6/2008 Natural BFP but mc @ 5+ wks

kar1

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3

Wednesday, January 3rd 2007, 3:09pm

look very interesting , wouldn't mind knowing more about this
TTC 12 years

2 early losses

lots of ops and tx

both tubes removed

5th fresh short protocol
:BFP:

Tyler May born 5/5/2010 by emergency c section. Tyler is our sunshine

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Reg: Apr 23rd 2006

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4

Wednesday, January 3rd 2007, 4:11pm

This does sound interesting. I collected 8 eggs on my last ICSI but only half were mature to use. Would this help in silimiar situations? If anyone has any info that would be great.

Sam xx

Me 28 DH 32 [zx101]
1st ICSI Dec 05 8 eggs, 3 fert :BFN:
Left Tube removed June 06
2nd ICSI March 07 16 eggs, 7 fert:BFN:
3rd ICSI July 07 - 22 eggs, 5 fert :BFN:
4th ICSI Dec 07 with blasto, lovely eggs, slow development to blasto :BFN:

Jaid

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5

Wednesday, January 3rd 2007, 6:34pm

I think it is not available in the U.K.

We did check somewhere on the net but can't remember where.
Jaid
Me 35, DH 41 -TTC/since Apr04
Natural BFP-Jun05/M/C @ 6 weeks-Jul05
Blocked Tubes - Mar06
1st IVF - '06' bfn / 2nd IVF '06'- bfn
8th Mar 07 - Laparoscopy / Endo found & cleared.
Tried Naturally - July 07 - BFP
Have a beautiful baby girl.

Eeyore

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6

Wednesday, January 3rd 2007, 6:40pm

This was in The Guardian last week, hope it helps

Polly Curtis, health correspondent
Saturday December 30, 2006
The Guardian


Scientists have unveiled a new form of IVF which they claim is "better than nature" at getting some women pregnant and does not need high doses of potentially harmful hormones.

The method, which involves harvesting immature eggs and growing them outside the body, reduces the need to pump women with hormones to mature the eggs internally. It has resulted in 400 healthy babies in Denmark and won the backing of Bob Edwards, the British scientist behind the first test-tube baby.

In vitro maturation (IVM) could drastically cut the risk of side-effects for the mother and reduce the drug bill, which in the UK is mostly met by the patients.

Although the method has been discussed for years, the Danish doctors were the first to use it successfully on a large scale and track the results. A healthy 30-year-old woman who has regular periods has a 20% chance of getting pregnant through intercourse each month, but the group who received the new treatment had a success rate of 30%, they found.

The eggs are removed from the woman's ovaries before they are fully developed, then small quantities of hormones are applied in the laboratory to mature them. They are then fertilised before being implanted back in the woman's womb, as in regular IVF. The treatment avoids the need to give women hormones to help them produce extra eggs, then more to get them all matured internally.

Svend Lindenberg, the Danish professor at the Nordic Fertility Centre in Copenhagen, which is testing the method, said: "The doctor now has a tool ... which can minimise the risks involved in IVF. We now have a more comfortable treatment for women and we haven't seen any problems in any of the babies who have been born as a result."

He added: "If you have a 30-year-old woman who menstruates regularly she will conceive every five months. That's a 20% chance. With this method some women will have a 30% chance.

"For women who were eligible for the treatment the success rate is better than what you can expect naturally."

Professor Lindenberg presented the research at a closed meeting of the International Society of Natural Cycle Assisted Reproduction in December. The organisation is campaigning for governments to refine the IVF available to women to reduce the amount of drugs they take.

Professor Edwards, who in 1978 helped to create the world's first test-tube baby, Louise Brown, has called for a rethink of IVF to capitalise on less aggressive treatment, including IVM. Speaking at the same conference, he said the improved IVM techniques were developing so rapidly that they could make IVF "very different in a year or two". He told his audience: "The field is thus now wide open, with clinics worldwide improving their methods of maturation in vitro as happened [in] ... the earlier days of IVF."

Traditional IVF drugs can cause ovarian hyperstimulation syndrome in around 5% of women. The symptoms include abdominal pain and swelling as the ovaries go into overdrive and produce too much fluid. In 1% to 2% of women undergoing IVF the fluids leak into the abdomen and can cause thrombosis.

The new technique is only beneficial for about 12% of women seeking IVF who are under 37 and have particular fertility problems which mean they produce lots of eggs but still fail to get pregnant. But this group includes women who have polycystic ovary syndrome and those most at risk of side-effects.

Previous attempts at IVM have been less successful because it was offered to all women and used different techniques, including less hospitable solutions in the Petri dish where the eggs are fertilised.

In Denmark the drug bill had been reduced from £1,400 to £140 a cycle, said Prof Lindenberg. People can spend tens of thousands of pounds trying to become parents in Britain, where NHS provision of IVF is limited.

Some scientists in the UK urged caution. Professor Alison Murdoch, of the internationally respected Newcastle Fertility Centre, said: "IVM will be a fantastic thing to achieve but it won't be suitable for all women. There are still uncertainties. You're doing a process in a laboratory which will make a baby - you have to be absolutely sure the techniques are safe."


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7

Wednesday, January 3rd 2007, 6:45pm

wow that sounds fantastic!



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Eeyore

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8

Wednesday, January 3rd 2007, 7:50pm

http://www.britishfertilitysociety.org.u…ents/vitro.html

This may help too, from the British Fertility Society


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9

Wednesday, January 3rd 2007, 8:08pm

Interesting. Maybe in 20 years' time, we'll all talk about IVM as we talk about IVF now.




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