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jfox89

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Reg: Jul 27th 2014

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Sunday, July 27th 2014, 2:12pm

WAITING FOR OUR FIRST IVF/PGD SEX SELECTION CLINIC APPOINTMENT *FEELING ANXIOUS* WHAT TO EXPECT PLEASE SHARE

Hi everyone,

Me and my partner are currently waiting for our first PGD clinic appointment. We feel like we are in the dark with it all at the moment. Can anyone please share there experiences. Just so you know we are having to start PGD as my partner has Alports syndrome which is a genetic disease that will 100% pass to a girl if we was to have a girl. We both feel very strongly about not passing Alports on and so we are going to do PGD sex selection. The consultant geneticist has done research at Guys hospital for us and found that there has been couples who have been funded in our situation with the same disease so we have been referred to the PGD clinic.

My questions are:-

What's the usual process?
How long did it take you to find out when your first appointment was?
Was the appointment a long time away from finding out?
How can I prepare myself and my body for IVF?
Can you still drink alcohol or none at all? (I have stopped drinking at the minute as I am unsure if you can or not but I am scared people will think I am pregnant)
What was the timescale from been referred to starting treatment?

Yours thoughts and experiences would be much appreciated.

Many thanks

jfox89

Posts: 1,193

Reg: May 30th 2010

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Sunday, July 27th 2014, 8:42pm

Hi There!

Our family is a PGD success story! We have two lovely daughters through PGD. There is a single gene mutation in our family giving 50 % chance to pass it on (regardless of sex in our case). We were told the chances for success are around 20% per cycle and 50% after 3 cycles. PGD was great for us as we would not have wanted to terminate any pregnancy but still hoped to avoid passing the condition on.


My questions are:-

What's the usual process?


the PGD cycle itself is very similar to a "normal" IVF cycle, as in:

1) woman receives some sort of hormonal stimulation (exact details would depend on the clinic's choice as best for the patient as there are several protocols to choose from)
2) eggs are harvested from woman and fertilised with man's sperms. Sperm has to be injected (ICSI) to make sure genetic material comes from the embryo and not some extra sperm stuck to the egg etc everything has to be quite controlled
3) Hopefully some eggs will fertilise (usually not all) and some of the fertilised embryos will start to grow (again likely not all)
4) Those that reach day 3 and around 8 cell big will be tested: one or two cells are taken out for testing
5) Embryos are let recover and to grow further and in the mean time the tests are done
6) Hopefully some embryos would have survived for day 5 and some of them are also normal so 1 or 2 can be tzransferred back into the woman

How long did it take you to find out when your first appointment was?
Was the appointment a long time away from finding out?
What was the timescale from been referred to starting treatment?

This was our timeline:
went to GP late 2007 or early 2008
went to colon cancer specialist 2008 (probably not applicable for you)
went to genetic counsellor for initial appoinment 2008
genetic counsellor blood test to confirm mutation 2008
genetic counsellor a couple more times including advice on PGD and other options (I remember being quite frustrated at this point but they were really quite nice and not everyone knows as much about PGD as we did by that point)
being referred to fertility clinic (finally!!) 2009
initial meeting with PGD nurse at fertility clinic
basic fertility tests to see if we can at all be helped with ICSI-PGD
blood test from us and relatives 2009 to make PGD probes
loooooong wait for probes to be ready, more than a year but I heard they can be quicker nowadays.
Appointments with fertility and PGD specialists (we were proactive here as they wanted a joint meeting but could never organise this so we said we are happy to go twice just let us start please)
about to start in 2010 April when lovely news that we got approved for funding for 1 cycle
May 2010 PGD cycle successful!!!
2011 Daughter born :-)


How can I prepare myself and my body for IVF?

That's not a medical, but my personal advice: be healthy, but enjoy fun too, there is not need to go overboard and stress about it. General good things would be: normal healthy diet, drinking lots (I mean water), sleeping enough, exercise, taking folic acid.


Can you still drink alcohol or none at all? (I have stopped drinking at the minute as I am unsure if you can or not but I am scared people will think I am pregnant)
I didn't drink alcohol, but I have never drunk much so people were not suspicious. If I were you I would either drink in moderation very occasionally or would probably tell people you decided to stop drinking alcohol to whatever made up reason maybe you want to be healthier etc ;-)


Good luck xxx

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Reg: May 30th 2010

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Sunday, July 27th 2014, 8:50pm

And how is your partner doing? My partner is also the carrier in our family but we are lucky that he is so far doing well (touch wood) xx

    United Kingdom

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Reg: Dec 22nd 2008

Location: London

Children: Beautiful twin daughters and two grown up stepdaughters

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Sunday, July 27th 2014, 9:24pm

No real advice for you, but I had treatment at Guys and the team are amazing. I cycled with a girl who had PGD as part of her treatment and we both ended up with twins. Very best of luck to you.
Newly Wed

ICSI December 2008 - chemical pregnancy
ICSI May 2009 - BFN
FET September 2009 - BFP
Beautiful twin girls born 30 April 2010



jfox89

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Reg: Jul 27th 2014

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Sunday, July 27th 2014, 11:52pm

Thank you so much Rianon for your advice it is much much appreciated. Can I ask what is a probe? Feel so daft for not knowing. Lovely to hear a success story. My partner is really well thank you. His disease he has affects his kidneys so last year he had to have a kidney transplant and it was his sister that donated her kidney to him. It's over a year now since the operation and he is like a new man now. How is your partner? Hope he is keeping well.

Many thanks again

jfox89

jfox89

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Sunday, July 27th 2014, 11:53pm

Thank you for your kind words Newly We'd. Wow both got twins what a lovely gift.

Many thanks

jfox89

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Tuesday, July 29th 2014, 6:03pm

Hi jfox89,

You are not daft at all!! Sorry for not explaining it is certainly not a general term. The probe is for the geneticists to detect the important parts within the genes. They should be able to detect the mutation (or rather the lack of it for the healthy embryos) and also be sure that the examined genetic material is coming from the father and mother.

xx




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